Laboratory tests for protein C deficiency

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[Protein C deficiency].

Severe protein C deficiency (i.e. protein C activity <1 IU dL(-1)) is a rare autosomal recessive disorder that usually presents in the neonatal period with purpura fulminans (PF) and severe disseminated intravascular coagulation (DIC), often with concomitant venous thromboembolism (VTE). Recurrent thrombotic episodes (PF, DIC, or VTE) are common. Homozygotes and compound heterozygotes often pos...

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Ophthalmic manifestations of neonatal protein C deficiency.

Protein C is a vitamin K dependent plasma zymogen which acts by regulating coagulation by its specific inactivation of factors V and VII, and facilitates fibrinolysis by elevating circulating plasminogen activator levels. Protein C deficiency is a rare condition which predisposes to episodes ofpotentially blinding and lethal thromboembolism. In the newborn period, congenital protein C deficienc...

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Ischemic stroke due to protein C deficiency.

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ژورنال

عنوان ژورنال: American Journal of Hematology

سال: 2010

ISSN: 0361-8609,1096-8652

DOI: 10.1002/ajh.21679